PZ09
Modify Date: 2023-03-02 09:54:26
PZ09 structure
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Common Name | PZ09 | ||
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| CAS Number | 1132609-87-0 | Molecular Weight | 423.513 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 741.4±70.0 °C at 760 mmHg | |
| Molecular Formula | C25H25N7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 402.2±35.7 °C | |
Use of PZ09PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold); also shows high selectivity for CDK-2 (>200-fold), as well as a broader range of other kinases (<50% inhibition at 10 uM); PZ09 is a small-molecule inhibitor, the first tool to successfully interrogate aPKC signaling in cells. |
| Name | 4-{3-[4-(4-Methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline |
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| Synonym | More Synonyms |
| Description | PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold); also shows high selectivity for CDK-2 (>200-fold), as well as a broader range of other kinases (<50% inhibition at 10 uM); PZ09 is a small-molecule inhibitor, the first tool to successfully interrogate aPKC signaling in cells. |
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| References | References 1. Trujillo JI, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):908-11. 2. Kajimoto T, et al. Sci Signal. 2019 Jan 1;12(562). pii: eaat6662. doi: 10.1126/scisignal.aat6662. View Related Products by Target PKC |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 741.4±70.0 °C at 760 mmHg |
| Molecular Formula | C25H25N7 |
| Molecular Weight | 423.513 |
| Flash Point | 402.2±35.7 °C |
| Exact Mass | 423.217133 |
| LogP | 2.78 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.748 |
| Benzenamine, 4-[3-[4-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl]- |
| 4-{3-[7-(4-Methylpiperazin-1-Yl)-1h-Benzimidazol-2-Yl]-1h-Indazol-6-Yl}aniline |
| 4-{3-[4-(4-Methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline |