1132609-87-0

1132609-87-0 structure

Name: PZ09
Chemical Name: 4-{3-[4-(4-Methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline
CAS Number: 1132609-87-0
Molecular Formula: C₂₅H₂₅N₇
Molecular Weight: 423.513
Create Date: 2020-01-20 12:14:56
Modify Date: 2024-09-20 16:42:17
PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold); also shows high selectivity for CDK-2 (>200-fold), as well as a broader range of other kinases (<50% inhibition at 10 uM); PZ09 is a small-molecule inhibitor, the first tool to successfully interrogate aPKC signaling in cells.

Name	4-{3-[4-(4-Methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline
Synonyms	Benzenamine, 4-[3-[4-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl]- 4-{3-[7-(4-Methylpiperazin-1-Yl)-1h-Benzimidazol-2-Yl]-1h-Indazol-6-Yl}aniline 4-{3-[4-(4-Methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline

Description	PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold); also shows high selectivity for CDK-2 (>200-fold), as well as a broader range of other kinases (<50% inhibition at 10 uM); PZ09 is a small-molecule inhibitor, the first tool to successfully interrogate aPKC signaling in cells.
References	References 1. Trujillo JI, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):908-11. 2. Kajimoto T, et al. Sci Signal. 2019 Jan 1;12(562). pii: eaat6662. doi: 10.1126/scisignal.aat6662. View Related Products by Target PKC