L-Ascorbic acid 2-phosphate magnesium

Modify Date: 2024-01-06 12:02:45

L-Ascorbic acid 2-phosphate magnesium Structure
L-Ascorbic acid 2-phosphate magnesium structure
Common Name L-Ascorbic acid 2-phosphate magnesium
CAS Number 113170-55-1 Molecular Weight 278.393
Density N/A Boiling Point N/A
Molecular Formula C6H9O9P.3/2Mg Melting Point N/A
MSDS N/A Flash Point N/A

 Use of L-Ascorbic acid 2-phosphate magnesium


L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].

 Names

Name L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate
Synonym More Synonyms

 L-Ascorbic acid 2-phosphate magnesium Biological Activity

Description L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].
Related Catalog
Target

IC50: alkaline phosphatase (ALP); collagen formation; runx2A[2][3]

In Vitro L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect [1]. L-Ascorbic acid 2-phosphate (50 µM-250 µM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 µM AsA2-P and 10 nM dexamethasone (Dex), and 250 µM AsA2-P and 5 nM Dex[3]. Cell Viability Assay[1] Cell Line: Human corneal endothelial cells (HCECs)  Concentration: 0.1 mM; 0.3 mM; 1.5 mM Incubation Time: 2 to 3 weeks with medium exchange every 2 to 3 days Result: Stimulated HCEC cells growth.
References

[1]. Shima N, et al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8711-7.

[2]. Kurata S, et al. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.J Biol Chem. 1991 May 25;266(15):9997-10003.

[3]. Kyllönen L, et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro.Stem Cell Res Ther. 2013 Feb 15;4(1):17.

 Chemical & Physical Properties

Molecular Formula C6H9O9P.3/2Mg
Molecular Weight 278.393
Exact Mass 277.967804
PSA 169.22000

 Safety Information

Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36/37/39
HS Code 2835100000

 Customs

HS Code 2835100000

 Synonyms

trimagnesium,[(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-oxido-5-oxo-2H-furan-4-yl] phosphate
L-Ascorbic Acid 2-Phosphate Sesquimagnesium Salt Hydrate
Magnesium (5R)-5-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-2-oxo-2,5-dihydro-3-furanyl phosphate
MFCD08063372