24R-Calcipotriol

Modify Date: 2025-08-21 19:02:40

24R-Calcipotriol structure	Common Name	24R-Calcipotriol
	CAS Number	112827-99-3	Molecular Weight	412.60500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₄₀O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 24R-Calcipotriol

24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.IC50 value:Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

Name	20(R)-(3'(R)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-1(S),3(R)-dihydroxy-9,10-secopregna-5(Z),7(E),10(19)-triene
Synonym	More Synonyms

Description	24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.IC50 value:Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Cancer
References	[1]. Gocek, Elzbieta; Kielbinski, Marek; Baurska, Hanna et al. Different susceptibilities to 1,25-dihydroxyvitamin D3-induced differentiation of AML cells carrying various mutations. Leukemia Research (2010), 34(5), 649-657. [2]. Gocek, Elzbieta; Kielbinski, Marek; Wylob, Paulina et al. Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential. Steroids (2008), 73(14), 1359-1366. [3]. Wietrzyk, Joanna; Nevozhay, Dmitry; Filip, Beata et al. The antitumor effect of lowered doses of cytostatics combined with new analogs of vitamin D in mice. Anticancer Research (2007), 27(5A), 3387-3398. [4]. Wietrzyk, Joanna; Chodynski, Michal; Fitak, Hanna et al. Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anti-Cancer Drugs (2007), 18(4), 447-457.

Description

Related Catalog

Signaling Pathways >> Vitamin D Related >> VD/VDR

Research Areas >> Cancer

References

[1]. Gocek, Elzbieta; Kielbinski, Marek; Baurska, Hanna et al. Different susceptibilities to 1,25-dihydroxyvitamin D3-induced differentiation of AML cells carrying various mutations. Leukemia Research (2010), 34(5), 649-657.

[2]. Gocek, Elzbieta; Kielbinski, Marek; Wylob, Paulina et al. Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential. Steroids (2008), 73(14), 1359-1366.

[3]. Wietrzyk, Joanna; Nevozhay, Dmitry; Filip, Beata et al. The antitumor effect of lowered doses of cytostatics combined with new analogs of vitamin D in mice. Anticancer Research (2007), 27(5A), 3387-3398.

[4]. Wietrzyk, Joanna; Chodynski, Michal; Fitak, Hanna et al. Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anti-Cancer Drugs (2007), 18(4), 447-457.

Molecular Formula	C₂₇H₄₀O₃
Molecular Weight	412.60500
Exact Mass	412.29800
PSA	60.69000
LogP	5.09060
Storage condition	2-8℃

Vitamin D2 SO2 ...

CAS#:87680-65-7

24R-Calcipotriol

CAS#:112827-99-3

Literature: Calverley Tetrahedron, 1987 , vol. 43, # 20 p. 4609-4619

(S)-2-((1R,3aS,...

CAS#:112828-12-3

24R-Calcipotriol

CAS#:112827-99-3

Literature: Calverley Tetrahedron, 1987 , vol. 43, # 20 p. 4609-4619

Precursor 2
CAS#:87680-65-7 Vitamin D2 SO2 ... CAS#:112828-12-3 (S)-2-((1R,3aS,...
DownStream 0

(24R)-Calcipotriene

24R-Calcipotriol

24-Epi-Calcipotriol

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24R-Calcipotriol

Use of 24R-Calcipotriol

Names

24R-Calcipotriol Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.