Prasugrel-d5

Modify Date: 2024-01-01 22:16:57

Prasugrel-d5 Structure
Prasugrel-d5 structure
Common Name Prasugrel-d5
CAS Number 1127252-92-9 Molecular Weight 378.47
Density 1.3±0.1 g/cm3 Boiling Point 493.5±45.0 °C at 760 mmHg
Molecular Formula C20H15D5FNO3S Melting Point N/A
MSDS N/A Flash Point 252.3±28.7 °C

 Use of Prasugrel-d5


Prasugrel-d5 is deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[1].

 Names

Name Prasugrel-d5
Synonym More Synonyms

 Prasugrel-d5 Biological Activity

Description Prasugrel-d5 is deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Wijeyeratne YD, et al. Anti-platelet therapy: ADP receptor antagonists. Br J Clin Pharmacol. 2011 Oct;72(4):647-57.

[3]. Sugidachi A, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost. 2007 Jul;5(7):1545-51.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 493.5±45.0 °C at 760 mmHg
Molecular Formula C20H15D5FNO3S
Molecular Weight 378.47
Flash Point 252.3±28.7 °C
Exact Mass 378.146179
LogP 3.17
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.619

 Synonyms

Ethanone, 2-[2-(acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-(cyclopropyl-d5)-2-(2-fluorophenyl)-
Prasugrel-d5
5-[2-(2H5)Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate