WZ-4-49-8
Modify Date: 2025-08-24 21:04:54
WZ-4-49-8 structure
|
Common Name | WZ-4-49-8 | ||
|---|---|---|---|---|
| CAS Number | 1125594-27-5 | Molecular Weight | 618.793 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 856.4±75.0 °C at 760 mmHg | |
| Molecular Formula | C32H42N8O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 471.7±37.1 °C | |
Use of WZ-4-49-8WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM; displays an exceptional selectivity profile with a selectivity score of only 0.027 in a panel of 442 kinases; inhibits c-Fes-L145P autophosphorylation and microtubule association in at least a subset of cells, and potently inhibits c-Fes-L145P-mediated soft-agar colony growth; dramatically inhibits osteoclast differentiation in RAW 264.7 macrophage cell line. |
| Name | N6-[4-(1,4'-Bipiperidin-1'-yl)-2-ethoxyphenyl]-N4-[2-(isopropylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine |
|---|---|
| Synonym | More Synonyms |
| Description | WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM; displays an exceptional selectivity profile with a selectivity score of only 0.027 in a panel of 442 kinases; inhibits c-Fes-L145P autophosphorylation and microtubule association in at least a subset of cells, and potently inhibits c-Fes-L145P-mediated soft-agar colony growth; dramatically inhibits osteoclast differentiation in RAW 264.7 macrophage cell line. |
|---|---|
| References | References 1. Hellwig S, et al. Chem Biol. 2012 Apr 20;19(4):529-40. 2. Weir MC, et al. PLoS One. 2017 Jul 20;12(7):e0181178. View Related Products by Target c-Fes Kinase |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 856.4±75.0 °C at 760 mmHg |
| Molecular Formula | C32H42N8O3S |
| Molecular Weight | 618.793 |
| Flash Point | 471.7±37.1 °C |
| Exact Mass | 618.310059 |
| LogP | 3.45 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.648 |
| N6-[4-(1,4'-Bipiperidin-1'-yl)-2-ethoxyphenyl]-N4-[2-(isopropylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine |
| 1H-Pyrazolo[3,4-d]pyrimidine-4,6-diamine, N6-(4-[1,4'-bipiperidin]-1'-yl-2-ethoxyphenyl)-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- |