WZ-4-49-8

Modify Date: 2023-01-18 08:26:43

WZ-4-49-8 structure	Common Name	WZ-4-49-8
	CAS Number	1125594-27-5	Molecular Weight	618.793
	Density	1.3±0.1 g/cm3	Boiling Point	856.4±75.0 °C at 760 mmHg
	Molecular Formula	C₃₂H₄₂N₈O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	471.7±37.1 °C

Use of WZ-4-49-8

WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM; displays an exceptional selectivity profile with a selectivity score of only 0.027 in a panel of 442 kinases; inhibits c-Fes-L145P autophosphorylation and microtubule association in at least a subset of cells, and potently inhibits c-Fes-L145P-mediated soft-agar colony growth; dramatically inhibits osteoclast differentiation in RAW 264.7 macrophage cell line.

Name	N6-[4-(1,4'-Bipiperidin-1'-yl)-2-ethoxyphenyl]-N4-[2-(isopropylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
Synonym	More Synonyms

Description	WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM; displays an exceptional selectivity profile with a selectivity score of only 0.027 in a panel of 442 kinases; inhibits c-Fes-L145P autophosphorylation and microtubule association in at least a subset of cells, and potently inhibits c-Fes-L145P-mediated soft-agar colony growth; dramatically inhibits osteoclast differentiation in RAW 264.7 macrophage cell line.
References	References 1. Hellwig S, et al. Chem Biol. 2012 Apr 20;19(4):529-40. 2. Weir MC, et al. PLoS One. 2017 Jul 20;12(7):e0181178. View Related Products by Target c-Fes Kinase

Description

References

References 1. Hellwig S, et al. Chem Biol. 2012 Apr 20;19(4):529-40. 2. Weir MC, et al. PLoS One. 2017 Jul 20;12(7):e0181178. View Related Products by Target c-Fes Kinase

Density	1.3±0.1 g/cm3
Boiling Point	856.4±75.0 °C at 760 mmHg
Molecular Formula	C₃₂H₄₂N₈O₃S
Molecular Weight	618.793
Flash Point	471.7±37.1 °C
Exact Mass	618.310059
LogP	3.45
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.648

N6-[4-(1,4'-Bipiperidin-1'-yl)-2-ethoxyphenyl]-N4-[2-(isopropylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

1H-Pyrazolo[3,4-d]pyrimidine-4,6-diamine, N6-(4-[1,4'-bipiperidin]-1'-yl-2-ethoxyphenyl)-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

DC Chemicals Limited
China
Product Name: WZ-4-49-8
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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