BIM 23042 TFA

Modify Date: 2025-08-26 10:21:59

BIM 23042 TFA structure	Common Name	BIM 23042 TFA
	CAS Number	111857-96-6	Molecular Weight	1192.452
	Density	1.4±0.1 g/cm3	Boiling Point	1554.2±65.0 °C at 760 mmHg
	Molecular Formula	C₆₂H₇₃N₁₁O₉S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	893.7±34.3 °C

Use of BIM 23042 TFA

BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca2+ release[1][2][3].

Name	h-d-2-nal-cys-tyr-d-trp-lys-val-cys-2-nal-nh2
Synonym	More Synonyms

Description	BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca2+ release[1][2][3].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor Research Areas >> Neurological Disease
In Vitro	BIM 23042 (5 μM) 在 huNMBR 细胞中竞争性抑制 Neuromedin B 诱导的 [3H] 花生四烯酸释放，Ki 为 49 nM[1]。
In Vivo	BIM 23042 (10μg; 静脉给药; 单次推注) 可减轻神经源性肿胀和热和机械致敏[2]。 Animal Model: Mice were 25-30 g male C57BL/6[2] Dosage: 10 μg Administration: IV; a single bolus Result: Attenuated neurogenic swelling and thermal and mechanical sensitization.
References	[1]. R R Ryan, et al. Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur J Pharmacol. 1996 Jun 13;306(1-3):307-14. [2]. Santosh K Mishra, et al. A nociceptive signaling role for neuromedin B. J Neurosci. 2012 Jun 20;32(25):8686-95. [3]. M Orbuch, et al. Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Mol Pharmacol. 1993 Oct;44(4):841-50.

Density	1.4±0.1 g/cm3
Boiling Point	1554.2±65.0 °C at 760 mmHg
Molecular Formula	C₆₂H₇₃N₁₁O₉S₂
Molecular Weight	1192.452
Flash Point	893.7±34.3 °C
Exact Mass	1191.503418
PSA	412.45000
LogP	6.00
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.709

1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane-4-carboxamide, 10-(4-aminobutyl)-N-[(1R)-2-amino-1-(2-naphthalenylmethyl)-2-oxoethyl]-19-[[(2R)-2-amino-3-(2-naphthalenyl)-1-oxopropyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-7-(1-methylethyl)-6,9,12,15,18-pentaoxo-, (4R,7S,10S,13R,16S,19R)-

(4R,7S,10S,13R,16S,19R)-10-(4-Aminobutyl)-N-[(2R)-1-amino-3-(2-naphthyl)-1-oxo-2-propanyl]-19-{[(2R)-2-amino-3-(2-naphthyl)propanoyl]amino}-16-(4-hydroxybenzyl)-13-(1H-indol-3-ylmethyl)-7-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BIM23042TFA
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

GL Biochem (Shanghai) Ltd.
China
Product Name: (D-2-Nal5,Cys6·11,Tyr7,D-Trp8,Val10,2-Nal12)-Somatostatin-14 (5-12) amide
Price: $Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

BIM 23042 TFA suppliers

BIM 23042 TFA price

BIM 23042 TFA

Use of BIM 23042 TFA

Names

BIM 23042 TFA Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.