LB-205
Modify Date: 2025-08-24 22:05:26
LB-205 structure
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Common Name | LB-205 | ||
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| CAS Number | 1113025-86-7 | Molecular Weight | 343.445 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H21N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LB-205A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo; significantly enhances the migration of astrocytes and accelerates wound repair more effectively than SAHA and VPA; up-regulates the expression of NGF, phospho-TrkA, p-AKT, NF-κB, and Bcl-2, while down-regulates the expression of p75 NTR, phospho-JNK, and Bax. |
| Name | LB-205 |
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| Description | A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo; significantly enhances the migration of astrocytes and accelerates wound repair more effectively than SAHA and VPA; up-regulates the expression of NGF, phospho-TrkA, p-AKT, NF-κB, and Bcl-2, while down-regulates the expression of p75 NTR, phospho-JNK, and Bax. |
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| References | References 1. Lu J, et al. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21200-5. 2. Lu J, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52. View Related Products by Target HDAC |
| Molecular Formula | C18H21N3O2S |
|---|---|
| Molecular Weight | 343.445 |
| InChIKey | NJJPJDCYPCCRLT-UHFFFAOYSA-N |
| SMILES | O=C(CCCCCNC(=O)c1ccccc1S)Nc1cccnc1 |