LB-205

Names

[ Name ]:
LB-205

Biological Activity

[Description]:

A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo; significantly enhances the migration of astrocytes and accelerates wound repair more effectively than SAHA and VPA; up-regulates the expression of NGF, phospho-TrkA, p-AKT, NF-κB, and Bcl-2, while down-regulates the expression of p75 NTR, phospho-JNK, and Bax.

[References]

References 1. Lu J, et al. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21200-5. 2. Lu J, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52. View Related Products by Target HDAC

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₁N₃O₂S

[ Molecular Weight ]:
343.445

Related Compounds

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