H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH acetate salt

Modify Date: 2024-01-09 20:01:07

H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH acetate salt structure	Common Name	H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH acetate salt
	CAS Number	111119-28-9	Molecular Weight	715.75600
	Density	1.59 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₈H₄₉N₁₁O₁₁	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH acetate salt

GRGDSPK is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.

Name	(2S)-6-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[(2-aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]hexanoic acid
Synonym	More Synonyms

Description	GRGDSPK is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Peptides
In Vitro	GRGDSPK inhibits the adhesion of Rat PDL cells[1]. RGD-containing (GRGDSPK, 1.5 mM, 1.0 mM, and 0.5 mM) and RGD-mod-ified peptides impair the ability of sperm to fertilizebovine oocytes, illustrated by a reduction in cleavage in a dose-dependent manner[2].
Cell Assay	Proliferation assays are carried out in 48-well cell culture dishes coated with OCP or HL. In proliferation assays, 7.25×103 cells in 0.5 mL of culture medium are seeded in a 48-well dish. Culture medium is changed every 3 days. After 1, 6, 12, and 18 days of culture, plates are washed thrice with PBS to remove unattached cells, and attached cells are collected by trypsinization. The number of cells is counted using a hemocytometer.
References	[1]. Hatakeyama J, et al. Proliferation and adhesion of periodontal ligament cells on synthetic biominerals. Oral Dis. 2007 Sep;13(5):500-6. [2]. Sessions BR, et al. Effects of amino acid substitutions in and around the arginine-glycine-aspartic acid (RGD) sequence on fertilization and parthenogenetic development in mature bovine oocytes. Mol Reprod Dev. 2006 May;73(5):651-7.

Density	1.59 g/cm3
Molecular Formula	C₂₈H₄₉N₁₁O₁₁
Molecular Weight	715.75600
Exact Mass	715.36100
PSA	374.58000
Index of Refraction	1.672
Storage condition	2-8℃

MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

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Grgdspk

Gly-arg-gly-asp-ser-pro-lys