EPPTB
Modify Date: 2024-01-06 11:06:07
EPPTB structure
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Common Name | EPPTB | ||
|---|---|---|---|---|
| CAS Number | 1110781-88-8 | Molecular Weight | 378.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H21F3N2O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of EPPTBRo 5212773 (EPPTB) is a potent and selective trace amine-associated receptor 1 (TAAR1) antagonist (Ki=0.9 nM for mouse TAAR1), with no significant effects on other TAARs. TAAR1 is a G protein-coupled receptor (GPCR) that is nonselectively activated by endogenous metabolites of amino acids[1][2]. |
| Name | N-(3-ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethylbenzamide |
|---|---|
| Synonym | More Synonyms |
| Description | Ro 5212773 (EPPTB) is a potent and selective trace amine-associated receptor 1 (TAAR1) antagonist (Ki=0.9 nM for mouse TAAR1), with no significant effects on other TAARs. TAAR1 is a G protein-coupled receptor (GPCR) that is nonselectively activated by endogenous metabolites of amino acids[1][2]. |
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| Related Catalog | |
| In Vitro | Ro 5212773 (EPPTB) suppresses the excitability of hippocampal pyramidal neurons. EPPTB also reduceds seizure-like events (SLEs) and seizure activity[1]. Ro 5212773 blocks the TAAR1-mediated activation of an inwardly rectifying K+ current[2]. Ro 5212773 potently antagonizes cAMP production induced by activating mouse TAAR1 with 1.5 μM β-phenylethylamine (IC50=27.5 nM). cAMP levels are dose-dependently reduced by Ro 5212773 in HEK293 cells in the absence of TAAR1 agonist (IC50= 19 nM). EPPTB is significantly more potent in antagonizing cAMP production by mouse, as compared to rat (IC50= 4539 nM) and human (IC50= 7487 nM) TAAR1[2]. |
| References |
| Molecular Formula | C20H21F3N2O2 |
|---|---|
| Molecular Weight | 378.39 |
| Exact Mass | 378.15600 |
| PSA | 41.57000 |
| LogP | 5.09460 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
|---|
| EPPTB |
| RO5212773 |
| N-(3-ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide |
| BENZAMIDE, N-(3-ETHOXYPHENYL)-4-(1-PYRROLIDINYL)-3-(TRIFLUOROMETHYL)- |