S32826
Modify Date: 2025-08-26 19:05:22
S32826 structure
|
Common Name | S32826 | ||
|---|---|---|---|---|
| CAS Number | 1096770-84-1 | Molecular Weight | 397.49 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H36NO4P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of S32826S32826 is a potent autotaxin inhibitor, with an IC50 of 8.8 nM. S32826 shows similar inhibitory effects at various autotaxin isoforms (α, β and γ). S32826 inhibits LPA release from adipocytes[1]. |
| Name | S32826 disodium salt hydrate |
|---|---|
| Synonym | More Synonyms |
| Description | S32826 is a potent autotaxin inhibitor, with an IC50 of 8.8 nM. S32826 shows similar inhibitory effects at various autotaxin isoforms (α, β and γ). S32826 inhibits LPA release from adipocytes[1]. |
|---|---|
| Related Catalog | |
| Target |
Autotaxin:8.8 nM (IC50) |
| In Vitro | S32826 (0.001-10 μM; 10 days) dose-dependently inhibits the release of lyso-phosphatidic acid (LPA) by 3T3-F442A adipocytes with an IC50 of 90 nM and a maximal inhibition of 80% at 500 nM[1]. S32826 (1 μM; 24 h) inhibits Dexamethasone-induced increases in autotaxin (ATX) mRNA expression in HTM cells and lysoPLD activity in conditioned media. S32826 inhibits Dexamethasone-induced the phosphorylation of MLC and cofilin, mRNA upregulation of COL1A1 and COL4A1, and expression of α-SMA, fibronectin and collagen-1 in the HTM cells[2]. |
| In Vivo | Topical application of S32826 (2-10 mM; 2 h-5 d) decreases intraocular pressure (IOP) in a dose- and time-dependent manner in rabbits[2]. S32826 (∼2 µM; single intracameral injection) reduces the IOP in rabbits, with the ocular hypotensive response lasting for more than 48 hrs[2]. S32826 (10 mg/kg; p.o., i.p., s.c., and i.v.) shows poor in vivo stability and/or bioavailability[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H36NO4P |
| Molecular Weight | 397.49 |
| Exact Mass | 397.238190 |
| PSA | 96.44000 |
| LogP | 5.00 |
| Index of Refraction | 1.536 |
| InChIKey | OUXAHVRWFHOKHY-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCC(=O)Nc1ccc(CP(=O)(O)O)cc1 |
| Hazard Codes | Xi |
|---|
|
~%
S32826 CAS#:1096770-84-1 |
| Literature: Jiang, Guowei; Madan, Damian; Prestwich, Glenn D. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 5098 - 5101 |
|
~%
S32826 CAS#:1096770-84-1 |
| Literature: Jiang, Guowei; Madan, Damian; Prestwich, Glenn D. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 5098 - 5101 |
|
~%
S32826 CAS#:1096770-84-1 |
| Literature: Jiang, Guowei; Madan, Damian; Prestwich, Glenn D. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 5098 - 5101 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| [4-(Tetradecanoylamino)benzyl]phosphonic acid |
| Phosphonic acid, [[4-[(1-oxotetradecyl)amino]phenyl]methyl]- |
| [4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt hydrate |
| [4-(tetradecanoylamino)phenyl]methylphosphonic acid |