AZD7624

Modify Date: 2025-08-25 17:47:26

Use of AZD7624

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

Name	3P4CR02JTD
Synonym	More Synonyms

Description	AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
Target	p38[1]
In Vitro	AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50u of 8.4, 8.7, and 9.0[1].
References	[1]. Pehrson R, et al. AZD7624, an Inhaled p38 Inhibitor, Demonstrates Local Lung Inhibition of LPS-Induced TNFα with Minimal Systemic Exposure. J Pharmacol Exp Ther. 2018 Jun;365(3):567-572.

Density	1.4±0.1 g/cm3
Molecular Formula	C₂₇H₃₀FN₅O₃
Molecular Weight	491.557
Exact Mass	491.233276
LogP	1.59
Index of Refraction	1.661
InChIKey	NNKPHNTWNILINE-UHFFFAOYSA-N
SMILES	CNCCOc1ccccc1C1(Nc2nccn(-c3cc(C(=O)NC4CC4)cc(F)c3C)c2=O)CC1

N-Cyclopropyl-3-fluoro-4-methyl-5-{3-[(1-{2-[2-(methylamino)ethoxy]phenyl}cyclopropyl)amino]-2-oxo-1(2H)-pyrazinyl}benzamide

Benzamide, N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-

3P4CR02JTD

AZD7624

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