Roflupram

Modify Date: 2024-01-02 10:03:46

Roflupram structure	Common Name	Roflupram
	CAS Number	1093412-18-0	Molecular Weight	314.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₀F₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Roflupram

Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors[1][2].

Name	Roflupram

Description	Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	PDE4:26.2 nM (IC50)
References	[1]. Li D, et, al. Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway. Int Immunopharmacol. 2021 Jan;90:107176. [2]. You T, et, al. Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS Chem Neurosci. 2017 Nov 15;8(11):2381-2392.

Molecular Formula	C₁₆H₂₀F₂O₄
Molecular Weight	314.32

Roflupram

Use of Roflupram

Names

Roflupram Biological Activity

Chemical & Physical Properties