GPLGIAGQ

Modify Date: 2025-08-24 19:50:44

GPLGIAGQ Structure
GPLGIAGQ structure
Common Name GPLGIAGQ
CAS Number 109053-09-0 Molecular Weight 711.81
Density N/A Boiling Point N/A
Molecular Formula C31H53N9O10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GPLGIAGQ


GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT)[1][2][3].

 Names

Name GPLGIAGQ

 GPLGIAGQ Biological Activity

Description GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT)[1][2][3].
Related Catalog
Target

MMP2[1].

In Vitro GPLGIAGQ is used to trigger PEG deshielding of liposomal carriers, resulting in enhanced cellular internalization[3].
References

[1]. Hou W, et al. MMP2-Targeting and Redox-Responsive PEGylated Chlorin e6 Nanoparticles for Cancer Near-Infrared Imaging and Photodynamic Therapy. ACS Appl Mater Interfaces. 2016 Jan 20;8(2):1447-57.

[2]. Zhu L, et al. Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials. 2014 Apr;35(13):4213-22.

[3]. Liu FH, et al. Enzyme-sensitive cytotoxic peptide-dendrimer conjugates enhance cell apoptosis and deep tumor penetration. Biomater Sci. 2018 Feb 27;6(3):604-613.

 Chemical & Physical Properties

Molecular Formula C31H53N9O10
Molecular Weight 711.81
InChIKey BLNMYSBCIVAVFK-PFZXUFBWSA-N
SMILES CCC(C)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C1CCCN1C(=O)CN)C(=O)NC(C)C(=O)NCC(=O)NC(CCC(N)=O)C(=O)O
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