GPLGIAGQ

Modify Date: 2024-01-03 09:19:29

GPLGIAGQ structure	Common Name	GPLGIAGQ
	CAS Number	109053-09-0	Molecular Weight	711.81
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₅₃N₉O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GPLGIAGQ

GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT)[1][2][3].

Name	GPLGIAGQ

Description	GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT)[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP2[1].
In Vitro	GPLGIAGQ is used to trigger PEG deshielding of liposomal carriers, resulting in enhanced cellular internalization[3].
References	[1]. Hou W, et al. MMP2-Targeting and Redox-Responsive PEGylated Chlorin e6 Nanoparticles for Cancer Near-Infrared Imaging and Photodynamic Therapy. ACS Appl Mater Interfaces. 2016 Jan 20;8(2):1447-57. [2]. Zhu L, et al. Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials. 2014 Apr;35(13):4213-22. [3]. Liu FH, et al. Enzyme-sensitive cytotoxic peptide-dendrimer conjugates enhance cell apoptosis and deep tumor penetration. Biomater Sci. 2018 Feb 27;6(3):604-613.

Molecular Formula	C₃₁H₅₃N₉O₁₀
Molecular Weight	711.81

GPLGIAGQ

Use of GPLGIAGQ

Names

GPLGIAGQ Biological Activity

Chemical & Physical Properties