RIOK2-IN-1
Modify Date: 2025-08-27 07:21:48
RIOK2-IN-1 structure
|
Common Name | RIOK2-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 1088216-72-1 | Molecular Weight | 276.33 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RIOK2-IN-1RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression[1]. |
| Name | RIOK2-IN-1 |
|---|
| Description | RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression[1]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C18H16N2O |
|---|---|
| Molecular Weight | 276.33 |
| InChIKey | HPQZTEVMVAVGJO-UHFFFAOYSA-N |
| SMILES | Cc1ccnc(NC(=O)Cc2ccc3ccccc3c2)c1 |