1088216-72-1
1088216-72-1 structure
- Name: RIOK2-IN-1
- Chemical Name: RIOK2-IN-1
- CAS Number: 1088216-72-1
- Molecular Formula: C18H16N2O
- Molecular Weight: 276.33
- Catalog: Research Areas Cancer
- Create Date: 2024-01-09 10:12:08
- Modify Date: 2025-08-27 07:21:48
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RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression[1].
| Name | RIOK2-IN-1 |
|---|
| Description | RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression[1]. |
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| Molecular Formula | C18H16N2O |
|---|---|
| Molecular Weight | 276.33 |