(S)-CR8

Modify Date: 2025-08-26 22:23:46

(S)-CR8 Structure
(S)-CR8 structure
 Common Name (S)-CR8
CAS Number 1084893-56-0 Molecular Weight 431.53300
Density N/A Boiling Point N/A
Molecular Formula C24H29N7O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (S)-CR8


(S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC50s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC50 0.40 μM)[1].

 Names

Name (2S)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol
Synonym More Synonyms

 (S)-CR8 Biological Activity

Description (S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC50s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC50 0.40 μM)[1].
Related Catalog
References

[1]. K Bettayeb, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807.

 Chemical & Physical Properties

Molecular Formula C24H29N7O
Molecular Weight 431.53300
Exact Mass 431.24300
PSA 104.01000
LogP 3.75900

 Synonyms

HMS3229B15
3lq5
SLQ
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Chemsrc provides (S)-CR8(CAS#:1084893-56-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of (S)-CR8 are included as well.>> amp version: (S)-CR8

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