ganoderic acid D

Modify Date: 2025-08-23 03:18:50

ganoderic acid D structure	Common Name	ganoderic acid D
	CAS Number	108340-60-9	Molecular Weight	514.650
	Density	1.2±0.1 g/cm3	Boiling Point	688.3±55.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₄₂O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	384.1±28.0 °C

Use of ganoderic acid D

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2].

Name	ganoderic acid D
Synonym	More Synonyms

Description	Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	SIRT3
References	[1]. Liu Z, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018 Apr 5;824:72-77. [2]. Yue QX，et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics. 2008 May;7(5):949-61.

Density	1.2±0.1 g/cm3
Boiling Point	688.3±55.0 °C at 760 mmHg
Molecular Formula	C₃₀H₄₂O₇
Molecular Weight	514.650
Flash Point	384.1±28.0 °C
Exact Mass	514.293030
PSA	125.81000
LogP	2.43
Vapour Pressure	0.0±4.9 mmHg at 25°C
Index of Refraction	1.559