Zamicastat
Modify Date: 2024-01-09 19:45:35
Zamicastat structure
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Common Name | Zamicastat | ||
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| CAS Number | 1080028-80-3 | Molecular Weight | 401.47300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H21F2N3OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ZamicastatZamicastat is a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8±7.2 μM and 17.0±2.7 μM, respectively. |
| Name | 4-[2-(benzylamino)ethyl]-3-[(3R)-6,8-difluoro-3,4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione |
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| Synonym | More Synonyms |
| Description | Zamicastat is a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8±7.2 μM and 17.0±2.7 μM, respectively. |
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| Related Catalog | |
| Target |
IC50: 73.8±7.2 μM (P-gp), 17.0±2.7 μM (BCRP)[1] |
| In Vitro | Zamicastat is a concentration-dependent dual P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor with IC50 values of 73.8±7.2 μM and 17.0±2.7 μM. Zamicastat also reversibly inhibits dopamine β-hydroxylase (DBH) without effect in brain tissue[1]. |
| References |
| Molecular Formula | C21H21F2N3OS |
|---|---|
| Molecular Weight | 401.47300 |
| Exact Mass | 401.13700 |
| PSA | 77.88000 |
| LogP | 4.34940 |
| Storage condition | 2-8℃ |
| Zamitat |
| UNII-YLU32D0DNV |