SNX-0723
Modify Date: 2024-01-08 17:00:43
SNX-0723 structure
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Common Name | SNX-0723 | ||
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| CAS Number | 1073969-18-2 | Molecular Weight | 399.47 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H26FN3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SNX-0723SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM; induces Hsp70 (IC50=31 nM), and decreases expression of several known Hsp90 client proteins:HER2 (IC50=9.4 nM), ribosomal protein s6 (pS6) (IC50=13 nM), and PERK (IC50=5.5 nM); shows significant brain concentrations along with induction of brain Hsp70 in vivo with promising PK properties. |
| Name | SNX-0723 |
|---|
| Description | SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM; induces Hsp70 (IC50=31 nM), and decreases expression of several known Hsp90 client proteins:HER2 (IC50=9.4 nM), ribosomal protein s6 (pS6) (IC50=13 nM), and PERK (IC50=5.5 nM); shows significant brain concentrations along with induction of brain Hsp70 in vivo with promising PK properties. |
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| References | References 1. Putcha P, J Pharmacol Exp Ther. 2010 Mar;332(3):849-57.et al. 2. McFarland NR, et al. PLoS One. 2014 Jan 20;9(1):e86048. 3. Neubert T, et al. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1338-42. View Related Products by Target Heat Shock Protein (HSP) |
| Molecular Formula | C22H26FN3O3 |
|---|---|
| Molecular Weight | 399.47 |