PRAZOBIND

Modify Date: 2025-08-25 18:47:32

PRAZOBIND structure	Common Name	PRAZOBIND
	CAS Number	107021-36-3	Molecular Weight	421.49200
	Density	1.323g/cm3	Boiling Point	706.6ºC at 760mmHg
	Molecular Formula	C₂₃H₂₇N₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	381.1ºC

Use of PRAZOBIND

Prazobind (SZL 49), a prazosin analog, is a potent alpha 1-adrenoceptor blocker. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50=1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes[1][2].

Name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(3-bicyclo[2.2.2]octa-2,5-dienyl)methanone
Synonym	More Synonyms

Description	Prazobind (SZL 49), a prazosin analog, is a potent alpha 1-adrenoceptor blocker. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50=1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
References	[1]. Mante S, et al. The alkylating prazosin analog SZL 49 inactivates both alpha 1A- and alpha 1B-adrenoceptors. Eur J Pharmacol. 1991;208(2):113-117. [2]. Piascik MT, Kusiak JW, Barron KW. Alpha 1-adrenoceptor subtypes and the regulation of peripheral hemodynamics in the conscious rat. Eur J Pharmacol. 1990;186(2-3):273-278.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

References

[1]. Mante S, et al. The alkylating prazosin analog SZL 49 inactivates both alpha 1A- and alpha 1B-adrenoceptors. Eur J Pharmacol. 1991;208(2):113-117.

[2]. Piascik MT, Kusiak JW, Barron KW. Alpha 1-adrenoceptor subtypes and the regulation of peripheral hemodynamics in the conscious rat. Eur J Pharmacol. 1990;186(2-3):273-278.

Density	1.323g/cm3
Boiling Point	706.6ºC at 760mmHg
Molecular Formula	C₂₃H₂₇N₅O₃
Molecular Weight	421.49200
Flash Point	381.1ºC
Exact Mass	421.21100
PSA	93.81000
LogP	2.98430
Vapour Pressure	8.22E-20mmHg at 25°C
Index of Refraction	1.665
InChIKey	MXXRJJCMLRPJOF-UHFFFAOYSA-N
SMILES	COc1cc2nc(N3CCN(C(=O)C4=CC5C=CC4CC5)CC3)nc(N)c2cc1OC

Bicyclo[2.2.2]o...

CAS#:117040-22-9

2-PIPERAZINE-4-...

CAS#:60547-97-9

~83%

PRAZOBIND

CAS#:107021-36-3

Literature: Pitha, Josef; Szabo, Lajos; Szurmai, Zoltan; Buchowiecki, Wieslaw; Kusiak, John W. Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 96 - 100

Bicyclo[2.2.2]o...

CAS#:102589-30-0

PRAZOBIND

CAS#:107021-36-3

Literature: Pitha, Josef; Szabo, Lajos; Szurmai, Zoltan; Buchowiecki, Wieslaw; Kusiak, John W. Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 96 - 100

cyclohexa-1,3-diene

CAS#:1165952-91-9

PRAZOBIND

CAS#:107021-36-3

Literature: Pitha, Josef; Szabo, Lajos; Szurmai, Zoltan; Buchowiecki, Wieslaw; Kusiak, John W. Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 96 - 100

Precursor 4
CAS#:117040-22-9 Bicyclo[2.2.2]o... CAS#:60547-97-9 2-PIPERAZINE-4-... CAS#:102589-30-0 Bicyclo[2.2.2]o... CAS#:1165952-91-9 cyclohexa-1,3-diene
DownStream 0

1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(bicyclo[2,2,2]octa-2,5-diene-2-carbonyl)piperazine

[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](bicyclo[2.2.2]octa-2,5-dien-2-yl)methanone

4-amino-2-[4-(bicyclo[2.2.2]octa-2,5-dien-2-ylcarbonyl)-piperazin-1-yl]-6,7-dimethoxyquinazoline

Methanone,[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]bicyclo[2.2.2]octa-2,5-dien-2-yl

Szl-49

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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PRAZOBIND
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.