HCAR2 agonist 1

HCAR2 agonist 1 structure	Common Name	HCAR2 agonist 1
	CAS Number	1066676-21-8	Molecular Weight	428.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₈N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HCAR2 agonist 1

HCAR2 agonist 1 (Compound 9n) is a Gi protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the Gi protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis[1].

Name	HCAR2 agonist 1

Description	HCAR2 agonist 1 (Compound 9n) is a Gi protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the Gi protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Zhao C, et al. Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation. Mol Cell. 2023 Sep 7;83(17):3171-3187.e7.

Molecular Formula	C₂₆H₂₈N₄O₂
Molecular Weight	428.53
InChIKey	DJSWNINDPRRCLC-GOSISDBHSA-N
SMILES	Cc1c(C(=O)NC(C)COc2ccccc2)cnc2c(-c3ccc(C(C)C)cc3)cnn12

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HCAR2 agonist 1

Use of HCAR2 agonist 1

Names

HCAR2 agonist 1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.