HCAR2 agonist 1

Names

[ CAS No. ]:
1066676-21-8

[ Name ]:
HCAR2 agonist 1

Biological Activity

[Description]:

HCAR2 agonist 1 (Compound 9n) is a Gi protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the Gi protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Zhao C, et al. Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation. Mol Cell. 2023 Sep 7;83(17):3171-3187.e7.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H28N4O2

[ Molecular Weight ]:
428.53

Related Compounds