Tafenoquine (Succinate)
Tafenoquine (Succinate) structure
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Common Name | Tafenoquine (Succinate) | ||
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| CAS Number | 106635-81-8 | Molecular Weight | 581.58100 | |
| Density | 1.237g/cm3 | Boiling Point | 565.6ºC at 760mmHg | |
| Molecular Formula | C28H34F3N3O7 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 295.9ºC | |
Use of Tafenoquine (Succinate)Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1]. |
| Name | butanedioic acid,4-N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine |
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| Synonym | More Synonyms |
| Description | Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1]. |
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| Related Catalog | |
| Target |
Anti-malarial[1] |
| In Vivo | Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg)[1]. |
| References |
| Density | 1.237g/cm3 |
|---|---|
| Boiling Point | 565.6ºC at 760mmHg |
| Molecular Formula | C28H34F3N3O7 |
| Molecular Weight | 581.58100 |
| Flash Point | 295.9ºC |
| Exact Mass | 581.23500 |
| PSA | 153.23000 |
| LogP | 6.61990 |
| Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| RIDADR | NONH for all modes of transport |
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Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania.
J. Antimicrob. Chemother. 66(11) , 2562-5, (2011) The present study was designed to elucidate the mechanism of tafenoquine uptake in Leishmania and its sterol dependence.Because tafenoquine is a fluorescent compound, spectrofluorimetric analysis allo... |
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Transmission-blocking activity of tafenoquine (WR-238605) and artelinic acid against naturally circulating strains of Plasmodium vivax in Thailand.
Am. J. Trop. Med. Hyg. 69(5) , 542-7, (2003) The sporontocidal activity of tafenoquine (WR-238605) and artelinic acid was determined against naturally circulating isolates of Plasmodium vivax in western Thailand. Primaquine was used as a negativ... |
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Military aviators, special operations forces, and causal malaria prophylaxis.
Mil. Med. 168(12) , 1001-6, (2003) U.S. military aviators are currently restricted to the use of chloroquine or doxycycline for malaria prophylaxis. Ground forces are allowed the additional option of taking mefloquine. These medication... |
| Tafenoquine succinate |
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| Tafenoquine Succinate |
| tafenoquine maleate |
| Etaquine |
| Tafenoquine (Succinate) |