Dafadine-A
Modify Date: 2024-01-11 06:32:17
Dafadine-A structure
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Common Name | Dafadine-A | ||
|---|---|---|---|---|
| CAS Number | 1065506-69-5 | Molecular Weight | 391.463 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 600.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C23H25N3O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 316.9±31.5 °C | |
Use of Dafadine-ADafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1). IC50 value:Target: DAF-9(CYP27A1) inhibitorThe DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematodeCaenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals. |
| Name | Dafadine-A |
|---|---|
| Synonym | More Synonyms |
| Description | Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1). IC50 value:Target: DAF-9(CYP27A1) inhibitorThe DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematodeCaenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 600.3±55.0 °C at 760 mmHg |
| Molecular Formula | C23H25N3O3 |
| Molecular Weight | 391.463 |
| Flash Point | 316.9±31.5 °C |
| Exact Mass | 391.189606 |
| LogP | 1.84 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.592 |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
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| Dafadine A |
| Methanone, [5-[(2,6-dimethylphenoxy)methyl]-3-isoxazolyl][4-(4-pyridinyl)-1-piperidinyl]- |
| Dafadine-A |
| MFCD13125955 |
| {5-[(2,6-Dimethylphenoxy)methyl]-1,2-oxazol-3-yl}[4-(4-pyridinyl)-1-piperidinyl]methanone |