Peptide T
Modify Date: 2025-08-20 21:50:41
Peptide T structure
|
Common Name | Peptide T | ||
|---|---|---|---|---|
| CAS Number | 106362-32-7 | Molecular Weight | 857.86200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C35H55N9O16 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Peptide TPeptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor. |
| Name | peptide T |
|---|---|
| Synonym | More Synonyms |
| Description | Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor. |
|---|---|
| Related Catalog | |
| Target |
CD4, HIV[1] |
| In Vitro | Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4[2]. Peptide T at 10-8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10-9 M concentration significantly inhibits IFN-g production by PBMC[3]. |
| In Vivo | Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE[4]. |
| Cell Assay | Peripheral blood mononuclear cells are stimulated with PHA (5 mg/mL) along with various concentrations of peptide T (10-6-10-12 M) for 48 h at 37°C. Supernatants are collected and frozen until analysis[3]. |
| Animal Admin | Rats[4] Peptide T (125, 250, 500, 800 μg) is randomly given subcutaneously to Female Lewis rats aged 6-8 weeks in the hind foot flanks in a final volume of 0.2 mL. Control animals receive the same volume of saline alone[4]. |
| References |
| Molecular Formula | C35H55N9O16 |
|---|---|
| Molecular Weight | 857.86200 |
| Exact Mass | 857.37700 |
| PSA | 431.49000 |
| Vapour Pressure | 0mmHg at 25°C |
| InChIKey | IWHCAJPPWOMXNW-LYKMMFCUSA-N |
| SMILES | CC(N)C(=O)NC(CO)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(=O)O)C(C)O)C(C)O)C(C)O)C(C)O |
| Storage condition | 2-8℃ |
| Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr |