Lei-Dab 7 TFA
Modify Date: 2025-08-27 11:54:45
Lei-Dab 7 TFA structure
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Common Name | Lei-Dab 7 TFA | ||
|---|---|---|---|---|
| CAS Number | 1061556-49-7 | Molecular Weight | 3394.07 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C141H236N46O39S6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Lei-Dab 7 TFALei-Dab7 is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. |
| Name | (Dab7)-Leiurotoxin I |
|---|
| Description | Lei-Dab7 is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. |
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| Related Catalog |
| Molecular Formula | C141H236N46O39S6 |
|---|---|
| Molecular Weight | 3394.07 |
| InChIKey | WEAKAAPTOACABK-HOSVXTCQSA-N |
| SMILES | CCC(C)C1NC(=O)C2CSSCC(NC(=O)C(Cc3ccccc3)NC(=O)C(C)N)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCN)C(=O)NC3CSSCC(NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)CNC1=O)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(N)=O)C(C)C)CSSCC(NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC3=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)N2 |