Cabotegravir Sodium

Modify Date: 2024-01-02 11:47:40

Cabotegravir Sodium Structure
Cabotegravir Sodium structure
Common Name Cabotegravir Sodium
CAS Number 1051375-13-3 Molecular Weight 427.334
Density N/A Boiling Point N/A
Molecular Formula C19H16F2N3NaO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cabotegravir Sodium


Cabotegravir sodium is a highly potent HIV integrase inhibitor with an IC50 value of 2.5 nM for HIVADA. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral drugs (ARVs)[1].

 Names

Name CABOTEGRAVIR SODIUM
Synonym More Synonyms

 Cabotegravir Sodium Biological Activity

Description Cabotegravir sodium is a highly potent HIV integrase inhibitor with an IC50 value of 2.5 nM for HIVADA. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral drugs (ARVs)[1].
Related Catalog
Target

IC50: 2.5 nM (HIVADA)[1]

References

[1]. Zhou T, et al. Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials. 2018 Jan;151:53-65.

 Chemical & Physical Properties

Molecular Formula C19H16F2N3NaO5
Molecular Weight 427.334
Exact Mass 427.095581

 Synonyms

S-265744B
Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, sodium salt, (3S,11aR)- (1:1)
3L12PT535M
CABOTEGRAVIR SODIUM
Sodium (3S,11aR)-8-[(2,4-difluorobenzyl)carbamoyl]-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazin-6-olate
GSK1265744B
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