Gü1303

Modify Date: 2024-01-10 11:49:38

Gü1303 Structure
Gü1303 structure
Common Name Gü1303
CAS Number 1043922-53-7 Molecular Weight 366.41
Density N/A Boiling Point N/A
Molecular Formula C20H22N4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Gü1303


Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen[1].

 Names

Name Gü1303

 Gü1303 Biological Activity

Description Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen[1].
Related Catalog
Target

Ki: 0.91 nM (mCatK)[1]

References

[1]. Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37(1):515-526.

 Chemical & Physical Properties

Molecular Formula C20H22N4O3
Molecular Weight 366.41
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