Gü1303

Names

[ Name ]:
Gü1303

Biological Activity

[Description]:

Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

Ki: 0.91 nM (mCatK)[1]

[References]

[1]. Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37(1):515-526.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₂N₄O₃

[ Molecular Weight ]:
366.41

Related Compounds

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