Eldecalcitol

Modify Date: 2024-01-02 10:30:02

Eldecalcitol Structure
Eldecalcitol structure
 Common Name Eldecalcitol
CAS Number 104121-92-8 Molecular Weight 490.715
Density 1.1±0.1 g/cm3 Boiling Point 655.7±55.0 °C at 760 mmHg
Molecular Formula C30H50O5 Melting Point 126-128ºC
MSDS N/A Flash Point 350.3±31.5 °C

 Use of Eldecalcitol


Eldecalcitol (ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3) is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density. IC50 value:Target: Vd analogEldecalcitol (ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3) is more efficacious than alfacalcidol in preventing vertebral and wrist fractures in osteoporotic patients with vitamin D sufficiency, with a safety profile similar to alfacalcidol.

 Names

Name (1S,2S,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropoxy)-4-methylidenecyclohexane-1,3-diol
Synonym More Synonyms

 Eldecalcitol Biological Activity

Description Eldecalcitol (ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3) is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density. IC50 value:Target: Vd analogEldecalcitol (ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3) is more efficacious than alfacalcidol in preventing vertebral and wrist fractures in osteoporotic patients with vitamin D sufficiency, with a safety profile similar to alfacalcidol.
Related Catalog
References

[1]. Matsumoto T.Osteoporosis Treatment by a New Active Vitamin D3 Compound, Eldecalcitol, in Japan.Curr Osteoporos Rep. 2012 Aug 24.

[2]. Shiraki M, et al. Eldecalcitol normalizes bone turnover markers regardless of their pre-treatment levels.Curr Med Res Opin. 2012 Aug 23.

[3]. Matsumoto T, Endo I.Eldecalcitol for the treatment of osteoporosis.Drugs Today (Barc). 2012 Mar;48(3):189-96.

[4]. Sakai S, et al.Combination therapy with eldecalcitol and alendronate has therapeutic advantages over monotherapy by improving bone strength.Bone. 2012 May;50(5):1054-63. Epub 2012 Feb 17.

[5]. Sanford M, McCormack PL.Spotlight on eldecalcitol in osteoporosis.Drugs Aging. 2012 Jan 1;29(1):69-71.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 655.7±55.0 °C at 760 mmHg
Melting Point 126-128ºC
Molecular Formula C30H50O5
Molecular Weight 490.715
Flash Point 350.3±31.5 °C
Exact Mass 490.365814
PSA 90.15000
LogP 5.84
Vapour Pressure 0.0±4.5 mmHg at 25°C
Index of Refraction 1.550
Storage condition 2-8℃

 Synthetic Route

 Synonyms

HY-A0020
ED 71
9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 2-(3-hydroxypropoxy)-, (1α,2β,3β,5Z,7E)-
UNII-I2JP8UE90H
Eldecalcitol
CS-0363
1,3-Cyclohexanediol, 2-(3-hydroxypropoxy)-4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,2R,3R,5Z)-
1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3
(1R,2R,3R,5Z,7E)-2-(3-Hydroxypropoxy)-9,10-secocholesta-5,7,10-triene-1,3,25-triol
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Related Compounds: More...
1β-eldecalcitol
158689-03-3
2β-trans-eldecalcitol
861996-34-1
Eldecalcitol Impurity 3
201854-22-0
Chemsrc provides Eldecalcitol(CAS#:104121-92-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Eldecalcitol are included as well.>> amp version: Eldecalcitol

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