MCH-1 antagonist 1 structure
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Common Name | MCH-1 antagonist 1 | ||
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CAS Number | 1039825-68-7 | Molecular Weight | 414.50000 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C25H26N4O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of MCH-1 antagonist 1MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM. |
Name | 4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one |
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Synonym | More Synonyms |
Description | MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM. |
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Related Catalog | |
Target |
MCH-1:2.6 nM (Ki) CYP3A4:10 μM (IC50) |
In Vitro | MCH-1 antagonist 1 (Compound 1) also inhibits cytochrome P450 3A4 (CYP3A4) with an IC50 of 10 μM[1]. |
In Vivo | MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile. Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC0-6 h of 14760 h*ng/mL[1]. |
References |
Molecular Formula | C25H26N4O2 |
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Molecular Weight | 414.50000 |
Exact Mass | 414.20600 |
PSA | 52.29000 |
LogP | 3.79990 |
Storage condition | 2-8℃ |
MCH-1 antagonist 1 |