Risedronic Acid-d4

Modify Date: 2024-01-08 15:25:33

Risedronic Acid-d4 Structure
Risedronic Acid-d4 structure
Common Name Risedronic Acid-d4
CAS Number 1035438-80-2 Molecular Weight 287.13700
Density N/A Boiling Point N/A
Molecular Formula C7H7D4NO7P2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Risedronic Acid-d4


Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid. Risedronic acid (Risedronate) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption[1][2].

 Names

Name 1-hydroxy-2-([2,4,5,6-2H4]-pyridin-3-yl)ethylidene-1,1-bisphosphonic acid
Synonym More Synonyms

 Risedronic Acid-d4 Biological Activity

Description Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid. Risedronic acid (Risedronate) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Giljevic Z, et al. Treatment of osteoporosis by risedronate-- speed, efficacy and safety. Reumatizam. 2006;53(2):66-71.

[3]. Jordao FM, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31.

 Chemical & Physical Properties

Molecular Formula C7H7D4NO7P2
Molecular Weight 287.13700
Exact Mass 287.02600
PSA 167.80000

 Synonyms

risedronic acid-d4
Risedronic acid-d4