D359-0396

Modify Date: 2024-01-03 06:24:12

D359-0396 structure	Common Name	D359-0396
	CAS Number	1031977-31-7	Molecular Weight	400.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₄N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of D359-0396

D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1β release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3, ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice[1].

Name	D359-0396

Description	D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1β release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3, ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
Target	NLRP3 inflammasome[1].
References	[1]. Li Z, et al. Identification of D359-0396 as a novel inhibitor of the activation of NLRP3 inflammasome. Neurochem Int. 2023 Oct;169:105565.

Molecular Formula	C₂₄H₂₄N₄O₂
Molecular Weight	400.47

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D359-0396

Use of D359-0396

Names

D359-0396 Biological Activity

Chemical & Physical Properties