1031977-31-7

1031977-31-7 structure

Name: D359-0396
Chemical Name: D359-0396
CAS Number: 1031977-31-7
Molecular Formula: C₂₄H₂₄N₄O₂
Molecular Weight: 400.47
Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
Create Date: 2023-12-22 09:44:41
Modify Date: 2024-01-03 06:24:12
D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1β release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3, ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice[1].

Name	D359-0396

Description	D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1β release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3, ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
Target	NLRP3 inflammasome[1].
References	[1]. Li Z, et al. Identification of D359-0396 as a novel inhibitor of the activation of NLRP3 inflammasome. Neurochem Int. 2023 Oct;169:105565.

Molecular Formula	C₂₄H₂₄N₄O₂
Molecular Weight	400.47