AEM1
Modify Date: 2025-09-18 08:23:59
AEM1 structure
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Common Name | AEM1 | ||
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| CAS Number | 1030123-90-0 | Molecular Weight | 379.408 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 582.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H14FN3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 305.9±30.1 °C | |
Use of AEM1NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC); broadly decreases the expression of Nrf2 controlled genes (HMOX1, GPX2), sensitizes A549 cells to various chemotherapeutic agents, and inhibits the growth of A549 cells in vitro and in vivo. |
| Name | N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine |
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| Synonym | More Synonyms |
| Description | NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC); broadly decreases the expression of Nrf2 controlled genes (HMOX1, GPX2), sensitizes A549 cells to various chemotherapeutic agents, and inhibits the growth of A549 cells in vitro and in vivo. |
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| References | References 1. Bollong MJ, et al. ACS Chem Biol. 2015 Oct 16;10(10):2193-8. View Related Products by Target Keap1-Nrf2 |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 582.1±50.0 °C at 760 mmHg |
| Molecular Formula | C20H14FN3O2S |
| Molecular Weight | 379.408 |
| Flash Point | 305.9±30.1 °C |
| Exact Mass | 379.079071 |
| LogP | 5.06 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.726 |
| InChIKey | QGYLTGSHWIGJJD-UHFFFAOYSA-N |
| SMILES | Fc1ccc(-c2csc3ncnc(NCc4ccc5c(c4)OCO5)c23)cc1 |
| Hazard Codes | Xi |
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| Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)- |
| MFCD15017488 |
| N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine |