4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine

Modify Date: 2025-08-21 11:22:33

4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine Structure
4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine structure
Common Name 4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine
CAS Number 10244-24-3 Molecular Weight 284.742
Density 1.3±0.1 g/cm3 Boiling Point 508.7±60.0 °C at 760 mmHg
Molecular Formula C12H17ClN4O2 Melting Point 139-142℃
MSDS N/A Flash Point 261.5±32.9 °C

 Names

Name 4,4'-(6-Chloropyrimidine-2,4-diyl)dimorpholine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 508.7±60.0 °C at 760 mmHg
Melting Point 139-142℃
Molecular Formula C12H17ClN4O2
Molecular Weight 284.742
Flash Point 261.5±32.9 °C
Exact Mass 284.104004
PSA 50.72000
LogP 0.83
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.576
Storage condition 2-8°C

 Safety Information

Hazard Codes T
Risk Phrases 25
Safety Phrases 45
HS Code 2934999090

 Synthetic Route

~92%

4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine Structure

4,4'-(6-chlorop...

CAS#:10244-24-3

Literature: NOVARTIS AG; CALIENNI, John Vincent; DE LA CRUZ, Marilyn; FLUBACHER, Dietmar; GONG, Baoqing; KAPA, Prasad Koteswara; KARPINSKI, Piotr H.; LIU, Hui; MICHEL, Pascal; MOSE, Rasmus; TESTA, Maria Caterina; WAYKOLE, Liladhar Murlidhar Patent: WO2012/44727 A2, 2012 ; Location in patent: Page/Page column 62-63 ;

~98%

4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine Structure

4,4'-(6-chlorop...

CAS#:10244-24-3

Literature: Burger, Matthew T.; Pecchi, Sabina; Wagman, Allan; Ni, Zhi-Jie; Knapp, Mark; Hendrickson, Thomas; Atallah, Gordana; Pfister, Keith; Zhang, Yanchen; Bartulis, Sarah; Frazier, Kelly; Ng, Simon; Smith, Aaron; Verhagen, Joelle; Haznedar, Joshua; Huh, Kay; Iwanowicz, Ed; Xin, Xiaohua; Menezes, Daniel; Merritt, Hanne; Lee, Isabelle; Wiesmann, Marion; Kaufman, Susan; Crawford, Kenneth; Chin, Michael; Bussiere, Dirksen; Shoemaker, Kevin; Zaror, Isabel; Maira, Sauveur-Michel; Voliva, Charles F. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 774 - 779

~57%

4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine Structure

4,4'-(6-chlorop...

CAS#:10244-24-3

Detail
Literature: WO2008/98058 A1, ; Page/Page column 57-58 ; WO 2008/098058 A1

~78%

4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine Structure

4,4'-(6-chlorop...

CAS#:10244-24-3

Literature: ACS Medicinal Chemistry Letters, , vol. 2, # 10 p. 774 - 779

~%

4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine Structure

4,4'-(6-chlorop...

CAS#:10244-24-3

Literature: WO2007/84786 A1, ; Page/Page column 123 ; WO 2007/084786 A1

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4,4'-(6-Chloro-2,4-pyrimidinediyl)dimorpholine
Morpholine, 4,4'-(6-chloro-2,4-pyrimidinediyl)bis-
4-(4-chloro-6-morpholin-4-ylpyrimidin-2-yl)morpholine
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