Ibudilast-d3

Modify Date: 2024-01-05 12:14:37

Ibudilast-d3 structure	Common Name	Ibudilast-d3
	CAS Number	102064-45-9	Molecular Weight	230.30600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₈N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ibudilast-d3

Ibudilast-d3 (KC-404-d3) is the deuterium labeled Ibudilast. Ibudilast (KC-404) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[1][2].

Name	2-methyl-1-(4,5,6,7-tetradeuterio-2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
Synonym	More Synonyms

Description	Ibudilast-d3 (KC-404-d3) is the deuterium labeled Ibudilast. Ibudilast (KC-404) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Mizuno T, et al. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology. 2004 Mar;46(3):404-11.

Molecular Formula	C₁₄H₁₈N₂O
Molecular Weight	230.30600
Exact Mass	230.14200
PSA	34.37000
LogP	3.29640

Hazard Codes	Xi

3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine-d3

AV 411-d3

1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one-d3

Ketas-d3

Ibudilast-d3 (Major)

KC 404-d3

2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone-d3

2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine-d3

Ibudilast-d3

Use of Ibudilast-d3

Names

Ibudilast-d3 Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms