MK-3577
Modify Date: 2024-04-05 22:57:52
MK-3577 structure
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Common Name | MK-3577 | ||
|---|---|---|---|---|
| CAS Number | 1019112-29-8 | Molecular Weight | 521.022 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 702.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C30H30ClFN2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 378.6±32.9 °C | |
Use of MK-3577A potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM; inhibits glucagon-mediated cAMP increases in CHO cells expressing the human glucagon receptor with IC50 of 8.3 nM. Diabetes Phase 2 Discontinued |
| Name | MK-3577 |
|---|---|
| Synonym | More Synonyms |
| Description | A potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM; inhibits glucagon-mediated cAMP increases in CHO cells expressing the human glucagon receptor with IC50 of 8.3 nM. Diabetes Phase 2 Discontinued |
|---|---|
| References | References 1. Peng JZ, et al. AAPS J. 2014 Nov;16(6):1259-70. View Related Products by Target Glucagon Receptor Diabetes |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 702.4±60.0 °C at 760 mmHg |
| Molecular Formula | C30H30ClFN2O3 |
| Molecular Weight | 521.022 |
| Flash Point | 378.6±32.9 °C |
| Exact Mass | 520.192871 |
| LogP | 7.03 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.626 |
| β-Alanine, N-[4-[(1S)-1-[(R)-(4-chlorophenyl)(7-fluoro-5-methyl-1H-indol-3-yl)methyl]butyl]benzoyl]- |
| MK-3577 |
| N-{4-[(1R,2S)-1-(4-Chlorophenyl)-1-(7-fluoro-5-methyl-1H-indol-3-yl)-2-pentanyl]benzoyl}-β-alanine |