SPC4061

Modify Date: 2025-09-07 17:45:33

SPC4061 Structure
SPC4061 structure
Common Name SPC4061
CAS Number 1018108-22-9 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SPC4061


SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases[1][2].

 Names

Name SPC4061

 SPC4061 Biological Activity

Description SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases[1][2].
Related Catalog
In Vitro SPC4061 降低了处理细胞中 PCSK9 mRNA 的水平[1]。
In Vivo SPC4061 (首先皮下注射 20 mg/kg, 24 小时后在第 7-28 天注射 5 mg/kg; 每周一次, 共 4 周) 导致猴子模型中产生的血清 PCSK9 蛋白水平的显著降低[1]。
References

[1]. Lindholm MW, et al. PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates. Mol Ther. 2012 Feb;20(2):376-81.  

[2]. Li Chuan-Yuan, et al. PCSK9 inhibitor compositions and methods for the treatment of cancer associated with PCSK9 expression: World Intellectual Property Organization, WO2020005869 A2 2020-01-02.

 Chemical & Physical Properties

No Any Chemical & Physical Properties
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