SPC4061

Names

[ Name ]:
SPC4061

Biological Activity

[Description]:

SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Metabolic Disease

[In Vitro]

SPC4061 降低了处理细胞中 PCSK9 mRNA 的水平[1]。

[In Vivo]

SPC4061 (首先皮下注射 20 mg/kg, 24 小时后在第 7-28 天注射 5 mg/kg; 每周一次, 共 4 周) 导致猴子模型中产生的血清 PCSK9 蛋白水平的显著降低[1]。

[References]

[1]. Lindholm MW, et al. PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates. Mol Ther. 2012 Feb;20(2):376-81.

[2]. Li Chuan-Yuan, et al. PCSK9 inhibitor compositions and methods for the treatment of cancer associated with PCSK9 expression: World Intellectual Property Organization, WO2020005869 A2 2020-01-02.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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