Dobutamine tartrate
Modify Date: 2024-01-08 19:10:49
Dobutamine tartrate structure
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Common Name | Dobutamine tartrate | ||
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| CAS Number | 101626-66-8 | Molecular Weight | 451.47 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H29NO9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Dobutamine tartrateDobutamine tartrate is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine tartrate is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine tartrate can increase cardiac output and correct hypoperfusion[1][2][3][4]. |
| Name | Dobutamine tartrate |
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| Description | Dobutamine tartrate is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine tartrate is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine tartrate can increase cardiac output and correct hypoperfusion[1][2][3][4]. |
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| Related Catalog | |
| In Vivo | Dobutamine tartrate has a rapid onset of action and a short half-life [2]. Dobutamine tartrate (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice[3]. Dobutamine tartrate results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice[3]. Low doses of Dobutamine tartrate significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice[3]. Dobutamine tartrate increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost[3]. Dobutamine tartrate increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation[4]. Animal Model: Tgαq*44 mice (heart failure models)[3] Dosage: 0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose Administration: Intraperitoneal injection Result: Induced different response in cardiac function on a low and high dose in mice with with heart failure. |
| References |
| Molecular Formula | C22H29NO9 |
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| Molecular Weight | 451.47 |