sodium picosulfate
Modify Date: 2024-01-02 23:42:33
sodium picosulfate structure
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Common Name | sodium picosulfate | ||
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| CAS Number | 10040-45-6 | Molecular Weight | 499.42 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H13NNa2O8S2.H2O | Melting Point | 272 - 275ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of sodium picosulfateSodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.Target: OthersSodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerate 1600 mg/mL Sodium Picosulfate. In human liver cultures the number of cells is slightly lowered at 800 and 1600 mg/mL and the number of nuclei in division is decreased dependent on dose [1]. Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study [2]. Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal [3]. |
| Name | Picosulfate Sodium |
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| Synonym | More Synonyms |
| Description | Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.Target: OthersSodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerate 1600 mg/mL Sodium Picosulfate. In human liver cultures the number of cells is slightly lowered at 800 and 1600 mg/mL and the number of nuclei in division is decreased dependent on dose [1]. Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study [2]. Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal [3]. |
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| Related Catalog | |
| References |
| Melting Point | 272 - 275ºC |
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| Molecular Formula | C18H13NNa2O8S2.H2O |
| Molecular Weight | 499.42 |
| PSA | 162.51000 |
| LogP | 4.10140 |
| Storage condition | Hygroscopic, Refrigerator, Under Inert Atmosphere |
| Water Solubility | Freely soluble in water, slightly soluble in ethanol 96 per cent. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2933399090 |
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| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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| Phenol, 4,4'-(2-pyridinylmethylene)bis-, bis(hydrogen sulfate) (ester), sodium salt (1:2) |
| sodium picosulfate |
| Picosulfate Sodium |
| sodium picosulphate |
| Phenol, 4,4'-(2-pyridinylmethylene)bis-, 1,1'-bis(hydrogen sulfate), sodium salt (1:2) |
| Disodium (2-pyridinylmethylene)di-4,1-phenylene disulfate |
| Sodium picosulfate anhydrous |
| Disodium (pyridin-2-ylmethylene)di-4,1-phenylene disulfate |
| 4,4’-(2-pyridylmethylene)diphenyl bis(hydrogen sulfate) disodium salt |
| Picolax |
| (pyridin-2-ylmethylene)bis(4,1-phenylene) disodium bis(sulfate) |
| disodium,[4-[pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate |
| disodium (pyridin-2-ylmethanediyl)dibenzene-4,1-diyl disulfate |
| EINECS 233-120-9 |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: sodium picosulfate
- Price: ￥1166.0/100mg ￥506.0/10mg ￥676.0/50mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Sodium picosulfate
- Price: $350.0/100mg $700.0/250mg $1400.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: SODIUM PICOSULFATE
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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Price: $66/10mM*1mLinDMSO
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