Ipatasertib-NH2
Modify Date: 2025-10-10 08:24:36
Ipatasertib-NH2 structure
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Common Name | Ipatasertib-NH2 | ||
|---|---|---|---|---|
| CAS Number | 1001382-14-4 | Molecular Weight | 415.92 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H26ClN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ipatasertib-NH2Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 (HY-133120) to degrade AKT[1]. |
| Name | Ipatasertib-NH2 |
|---|
| Description | Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 (HY-133120) to degrade AKT[1]. |
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| Related Catalog | |
| Target |
AKT[1] |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
| Molecular Formula | C21H26ClN5O2 |
|---|---|
| Molecular Weight | 415.92 |
| InChIKey | FKWGZLUCQAOQDJ-KBRIMQKVSA-N |
| SMILES | CC1CC(O)c2ncnc(N3CCN(C(=O)C(CN)c4ccc(Cl)cc4)CC3)c21 |
| Storage condition | -20°C |