83881-59-8

83881-59-8 structure

Name: Cetirizine Impurity C
Chemical Name: 2-[2-[4-[(2-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
CAS Number: 83881-59-8
Molecular Formula: C₂₁H₂₅ClN₂O₃
Molecular Weight: 388.888
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2016-04-18 11:47:35
Modify Date: 2025-09-27 13:41:50
Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist[1][2].

Name	2-[2-[4-[(2-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
Synonyms	2-Chlorocetirizine Cetirizine 2-Chloro Impurity Dihydrochloride Acetic acid, 2-[2-[4-[(2-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]- UNII-4DG59P89YF Cetirizine impurity C UNII:4DG59P89YF (2-{4-[(2-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetic acid

Description	Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
References	[1]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. [2]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.