Name | 2-[[4-carboxy-4-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]butyl]carbamoyl]benzoic acid |
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Description | Talotrexin (PT523), an analog of Aminopterin (HY-14518), is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth[1][2]. |
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Related Catalog | |
In Vitro | Talotrexin 未显示出显著的 PCFT 或 FRα 抑制活性[1]。 Talotrexin (1-1000 nM) 可抑制 R1-11/Tet-on-RFC HeLa 细胞的增殖[2]。 |
In Vivo | Talotrexin (0-35 mg/kg,静脉注射,每周一次,持续 4 周) 单独或与Paclitaxel (HY-B0015, 7.5 mg/kg) 联合使用可抑制小鼠 A549 肿瘤的生长[2]。 Animal Model: NSCLC xenografts in athymic female nude mice (6-8 weeks)[2] Dosage: 15, 25, and 35 mg/kg, combined with Paclitaxel (HY-B0015, 7.5 mg/kg) Administration: IV injection, once weekly for 4 weeks Result: Inhibited A549 tumor growth. |
References |
Density | 1.51g/cm3 |
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Molecular Formula | C27H27N9O6 |
Molecular Weight | 573.56000 |
Exact Mass | 573.20800 |
PSA | 248.43000 |
LogP | 3.30490 |
Index of Refraction | 1.737 |