183293-82-5

183293-82-5 structure

Name: Gemcabene
Chemical Name: 6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid
CAS Number: 183293-82-5
Molecular Formula: C₁₆H₃₀O₅
Molecular Weight: 302.40600
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-03-23 01:59:34
Modify Date: 2025-08-27 15:10:11
Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].

Name	6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid
Synonyms	Gemcabene UNII-B96UX1DDKS

Description	Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vitro	Gemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2)[3].
References	[1]. Mandema JW, et al. Model-based development of gemcabene, a new lipid-altering agent. AAPS J. 2005 Oct 7;7(3):E513-22. [2]. Srivastava RAK, et al. Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain. Front Pharmacol. 2018 May 11;9:471. [3]. Oniciu DC, et al. Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH. PLoS One. 2018 May 30;13(5):e0194568.

6334-96-9

79-31-2

~57%

183293-82-5

Literature: SSV THERAPEUTICS, INC. Patent: WO2008/18877 A1, 2008 ; Location in patent: Page/Page column 38 ;

6334-96-9

802294-64-0

~30%

183293-82-5

1044741-19-6

Literature: Zhang, Yinsheng; Jian, Zhigang; Hong, Yang Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 5-6 p. 602 - 604