Gemcabene

Modify Date: 2025-08-27 15:10:11

Gemcabene structure	Common Name	Gemcabene
	CAS Number	183293-82-5	Molecular Weight	302.40600
	Density	1.048g/cm3	Boiling Point	453.6ºC at 760mmHg
	Molecular Formula	C₁₆H₃₀O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	156.7ºC

Use of Gemcabene

Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].

Name	6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid
Synonym	More Synonyms

Description	Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vitro	Gemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2)[3].
References	[1]. Mandema JW, et al. Model-based development of gemcabene, a new lipid-altering agent. AAPS J. 2005 Oct 7;7(3):E513-22. [2]. Srivastava RAK, et al. Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain. Front Pharmacol. 2018 May 11;9:471. [3]. Oniciu DC, et al. Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH. PLoS One. 2018 May 30;13(5):e0194568.

Density	1.048g/cm3
Boiling Point	453.6ºC at 760mmHg
Molecular Formula	C₁₆H₃₀O₅
Molecular Weight	302.40600
Flash Point	156.7ºC
Exact Mass	302.20900
PSA	83.83000
LogP	3.56520
Vapour Pressure	1.72E-09mmHg at 25°C
Index of Refraction	1.473
Storage condition	2-8℃

1,1′-OXYBIS(4-C...

CAS#:6334-96-9

Isobutyric acid

CAS#:79-31-2

~57%

Gemcabene

CAS#:183293-82-5

Literature: SSV THERAPEUTICS, INC. Patent: WO2008/18877 A1, 2008 ; Location in patent: Page/Page column 38 ;

1,1′-OXYBIS(4-C...

CAS#:6334-96-9

N/A

CAS#:802294-64-0

~30%

Gemcabene

CAS#:183293-82-5

6-(4-chlorobuto...

CAS#:1044741-19-6

Literature: Zhang, Yinsheng; Jian, Zhigang; Hong, Yang Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 5-6 p. 602 - 604

Gemcabene

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Gemcabene
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Gemcabene
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Gemcabene
Price: $650.0/100mg $1100.0/250mg $2200.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Gemcabene suppliers

Price: ￥1650/10 mM * 1 mL in DMSO

Reference only. check more Gemcabene price

Gemcabene

Use of Gemcabene

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Gemcabene Biological Activity

Chemical & Physical Properties

Synthetic Route

Synonyms

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