181477-43-0

181477-43-0 structure

Name: (Met186)-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) trifluoroacetate salt
Chemical Name: Disomotide
CAS Number: 181477-43-0
Molecular Formula: C₄₇H₇₄N₁₀O₁₄S
Molecular Weight: 1035.21
Catalog: Biochemical Amino acids and their derivatives Glutamine derivative
Create Date: 2018-09-23 18:01:56
Modify Date: 2024-01-10 13:42:19
Disomotide (G209-2M) is a melanoma antigen that enhances the generation of cytotoxic T lymphocytes (CTL) recognizing native G209 as well as melanoma[1][2].

Name	Disomotide
Synonyms	disomotide L-Isoleucyl-L-methionyl-L-α-aspartyl-L-glutaminyl-L-valyl-L-prolyl-L-phenylalanyl-L-seryl-L-valine L-Valine, L-isoleucyl-L-methionyl-L-α-aspartyl-L-glutaminyl-L-valyl-L-prolyl-L-phenylalanyl-L-seryl-

Description	Disomotide (G209-2M) is a melanoma antigen that enhances the generation of cytotoxic T lymphocytes (CTL) recognizing native G209 as well as melanoma[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	为了激活 Ag，用 Disomotide (G209-2M; 1 μM) 处理 PBMCs 6天[2]。
References	[1]. Yang S, et al. Antimelanoma activity of CTL generated from peripheral blood mononuclear cells after stimulation with autologous dendritic cells pulsed with melanoma gp100 peptide G209-2M is correlated to TCR avidity. J Immunol. 2002 Jul 1;169(1):531-9. [2]. Ahmadzadeh M, et al. IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells. J Immunother. 2007 Apr;30(3):294-302.